Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
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چکیده
منابع مشابه
Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria.
Transmission of cytosolic [Ca2+] ([Ca2+]c) oscillations into the mitochondrial matrix is thought to be supported by local calcium control between IP3 receptor Ca2+ channels (IP3R) and mitochondria, but study of the coupling mechanisms has been difficult. We established a permeabilized cell model in which the Ca2+ coupling between endoplasmic reticulum (ER) and mitochondria is retained, and mito...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2019
ISSN: 1465-7392,1476-4679
DOI: 10.1038/s41556-019-0329-y